The Leading Ketamine Clinic in Los Angeles since 2014!
10,000+
Infusions
Performed
2,000+
Patients
Helped
83%
Success
Rate
Ketamine Clinics of Los Angeles is a world-renowned, leading provider of Ketamine Infusion Therapy for the treatment of mood disorders and chronic pain.
What We Treat

The Ketamine Clinics Los Angeles (KCLA) team is compassionate, experienced, and knowledgeable, helping patients to feel at home during their treatments. Our state-of-the-art facility blends luxury amenities with cutting-edge medicine to create a spa-like, serene space for patients to enjoy one of the most effective treatments available for mood disorders and chronic pain.
Ketamine Clinics LA fosters a tight-knit team environment with committed employees who are highly-trained to master this specialized treatment. Our combined proficiency and expertise in ketamine medical uses surpasses that of any other provider or medical practice in the industry.
Press
The Doctors – Do Ketamine Clinics Need More Oversight?
Dr. Steven L. Mandel speaks on the Emmy award-winning TV show The Doctors about the oversight of Ketamine Clinics and where some doctors and other providers are crossing the line. He also educates viewers on ketamine’s multiple uses and the fact that it’s a depression treatment, not a cure.
BuzzFeed Video – How A Drug Helps Me Cope With My Kids’ Suicides
Wired Magazine – People are using ketamine to fight their depression.
Our articulate patient, Sean, shares his struggle with depression as an entrepreneur who “has it all” and how ketamine treatments helped him enjoy life again and function at a higher level. This WIRED Magazine video special also covers why Ketamine Infusions are such an effective treatment for depression. Thank you for sharing your story, Sean.
Research
Ketamine as a Novel Treatment for Major Depressive Disorder and Bipolar Depression: A Systematic Review and Quantitative Meta-Analysis
Given the significant disability, morbidity and mortality associated with depression, the promising recent trials of ketamine highlight a novel intervention. A meta-analysis was conducted to assess the efficacy of ketamine in comparison with placebo for the reduction of depressive symptoms in patients who meet criteria for a major depressive episode. The large and statistically significant effect of ketamine on depressive symptoms supports a promising, new and effective pharmacotherapy with rapid onset, high efficacy and good tolerability.
Antidepressant Efficacy of Ketamine in Treatment-Resistant Major Depression: A Two-Site Randomized Controlled Trial
The authors evaluated the rapid antidepressant efficacy of ketamine in a large group of patients with treatment-resistant major depression. Ketamine demonstrated rapid antidepressant effects in an optimized study design, further supporting NMDA receptor modulation as a novel mechanism for accelerated improvement in severe and chronic forms of depression.
Rapid Antidepressant Effects of Repeated Doses of Ketamine Compared with Electroconvulsive Therapy in Hospitalized Patients with Major Depressive Disorder
Accumulating evidence suggests that ketamine may exert rapid antidepressant effects in major depressive disorder patients. This study showed that ketamine is as effective as ECT in improving depressive symptoms in MDD patients and has more rapid antidepressant effects compared with the ECT.
Dr. Steven L. Mandel
Steven L. Mandel, M.D. is the founder and president of Ketamine Clinics Los Angeles, among the first and most prestigious Ketamine Clinics in the United States. He is a board-certified anesthesiologist with a master’s degree in psychology, enabling him to have a unique perspective on this specialized treatment; Dr. Mandel is the only ketamine provider with this dual background. He has over 35 years of experience practicing medicine in both inpatient and outpatient settings. Dr. Mandel is also a founding member and the first president of the American Society of Ketamine Physicians (ASKP), a non-profit organization dedicated to the safe, ethical, therapeutic use of ketamine for mood disorders and pain conditions.

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