The Leading Ketamine Clinic in Los Angeles since 2014!

Ketamine Clinics Los Angeles is a world-renowned, leading provider of Ketamine Therapy for the treatment of mood disorders. Since 2014, our mission has been to help those struggling with treatment-resistant conditions through an innovative, evidence-based, compassionate solution.







4 days



Side Effects

Over 83% of our mood disorder patients experience relief from their symptoms. Most patients see improvement in as fast as 4 hours to 4 days from when they start treatment. There are no known long-term side effects and the short-term side effects are well tolerated and usually dissipate within one day. All of these factors make Ketamine Infusion Therapy one of the fastest, most effective, and safest mood disorder treatments available today.


Ketamine for Depression and other Mood Disorders

At Ketamine Clinics of Los Angeles, we offer patients a personalized approach to mental health treatment, with ketamine infusions for depression, suicidal thinking, post-traumatic stress disorder (PTSD), anxiety, and other mood disorders. As one of the first Ketamine Clinics in the United States and the first and only Ketamine Clinic to be accredited by AAAASF, we consistently set the gold-standard for patient comfort, safety, and optimum treatment outcomes.

What We Treat


Patients undergoing Ketamine Infusion Therapy for depression, unipolar depression, bipolar depression, postpartum depression (PPD), can feel rapid relief within hours to days, without the negative side effects associated with antidepressant medications. Ketamine infusions for depression can be highly effective even in treatment-resistant cases. This return to wellness can last many months and even years in some cases, oftentimes eliminating the need to take antidepressants every day. Most patients also report a superior quality of relief; a genuine sense of happiness without the flat or numb affect often experienced from other treatments. Treatment is safe, effective, and has no long-term side effects.


Mood Disorders

Patients suffering from mood disorders such as suicidal thoughts, post-traumatic stress disorder (PTSD), obsessive-compulsive disorder and (OCD) may experience considerably more relief from ketamine infusions than conventional medications and therapies provide. Ketamine therapy can work effectively, even in treatment-resistant cases, with no long-term side effects. Ketamine helps improve brain function and promotes healing in a unique way, unlike other traditional treatments. Most of ketamine’s effects on neurochemistry are an entirely new approach to treating mental health conditions. Treatment is safe, effective, and has no long-term side effects.


Anxiety Disorders

Patients with generalized anxiety disorder, social phobia, panic disorder, and other forms of anxiety disorders can be treated effectively and quickly by Ketamine Infusion Therapy. Relief is often enjoyed as fast as 2-3 infusions. Ketamine treatment can help to promote calm in a patient’s nervous system through a unique process of helping restore a healthier neurochemical balance. Reductions in dependency on traditional prescription drugs are seen in some patients. Most patients enjoy an overall healthier perspective on themselves and their lives. Treatment is safe, effective, and has no long-term side effects


The care team at Ketamine Clinics Los Angeles (KCLA) is known for being the most experienced, knowledgeable, and compassionate providers in this field. We help patients feel at home during their treatments. Our state-of-the-art facility is purpose-built for this unique treatment and no expense was spared. On the top floor of the esteemed Cedars-Sinai Kerlan Jobe building in the Playa District, we blend luxurious amenities with cutting-edge medicine to create a serene, spa-like space for patients to enjoy one of the most effective treatments available for mood disorders. At KCLA, the patient experience is our highest priority and our ability to consistently deliver one that is 5-stars is evident in our awards, press coverage, reputation within the medical community, and over 200 five-star reviews.

We’re proud to be the premier clinic for ketamine therapy Los Angeles trusts. We foster a tight-knit team environment with committed employees who are among the most experienced and highly-trained to master this specialized treatment. Our combined proficiency and expertise with IV Ketamine Infusions for depression and other mood disorders ensures the best possible treatment outcomes for you and those you care for.



The Doctors – Do Ketamine Clinics Need More Oversight?

Dr. Steven L. Mandel speaks on the Emmy award-winning TV show The Doctors about the oversight of Ketamine Clinics and where some doctors and other providers are crossing the line. He also educates viewers on ketamine’s multiple uses and the fact that it’s a depression treatment, not a cure.


BuzzFeed Video – How A Drug Helps Me Cope With My Kids’ Suicides

Ketamine Clinics Los Angeles patient Tom shares his heart-wrenching story of losing two sons to suicide and how he has found hope to continue living through Ketamine Infusion Therapy. Tom is incredibly brave to share his story and is an inspiration to people who have suffered horrible trauma. Thank you, Tom, for your courage.

Wired Magazine – People are using ketamine to fight their depression.

Our articulate patient, Sean, shares his struggle with depression as an entrepreneur who “has it all” and how ketamine treatments helped him enjoy life again and function at a higher level. This WIRED Magazine video special also covers why Ketamine Infusions are such an effective treatment for depression. Thank you for sharing your story, Sean.



Ketamine as a Novel Treatment for Major Depressive Disorder and Bipolar Depression: A Systematic Review and Quantitative Meta-Analysis

Given the significant disability, morbidity and mortality associated with depression, the promising recent trials of ketamine highlight a novel intervention. A meta-analysis was conducted to assess the efficacy of ketamine in comparison with placebo for the reduction of depressive symptoms in patients who meet criteria for a major depressive episode. The large and statistically significant effect of ketamine on depressive symptoms supports a promising, new and effective pharmacotherapy with rapid onset, high efficacy and good tolerability.

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Antidepressant Efficacy of Ketamine in Treatment-Resistant Major Depression: A Two-Site Randomized Controlled Trial

The authors evaluated the rapid antidepressant efficacy of ketamine in a large group of patients with treatment-resistant major depression. Ketamine demonstrated rapid antidepressant effects in an optimized study design, further supporting NMDA receptor modulation as a novel mechanism for accelerated improvement in severe and chronic forms of depression.

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Rapid Antidepressant Effects of Repeated Doses of Ketamine Compared with Electroconvulsive Therapy in Hospitalized Patients with Major Depressive Disorder

Accumulating evidence suggests that ketamine may exert rapid antidepressant effects in major depressive disorder patients. This study showed that ketamine is as effective as ECT in improving depressive symptoms in MDD patients and has more rapid antidepressant effects compared with the ECT.

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Dr. Steven L. Mandel

Dr. Steven L. Mandel, Founder & President, is an internationally recognized expert and pioneer in the use of ketamine infusion therapy to treat mental health disorders. Dr. Mandel has more than 40 years of experience utilizing ketamine as a board-certified anesthesiologist. He also earned his master’s degree in psychology. He is the founder and president of Ketamine Clinics Los Angeles, a leading ketamine infusion therapy clinic in Southern California.


Our Patients and What They Are Saying

Ketamine is effective in treating patients who have been diagnosed as “treatment-resistant,” meaning they have not responded to a fair trial of conventional medication. It is their condition, not them, that is resistant. Ketamine is better, works faster, and is safer than most alternatives. The quality of relief surpasses the alternatives. Ketamine Infusion Therapy is a highly unique treatment and there is no one more appropriate to prove it than our brave patients.

The patients we’ve treated who have benefitted from Ketamine Infusion Therapy run the gamut and include every type of person and every level of severity of symptoms. Children as young as 10, adults as old as 88, men, women, all genders, races, ethnicities, religious and cultural backgrounds, socioeconomic statuses, and more. Peoples’ ability to function and the type of work they do ranges from highly-functioning, highly-successful people to those disabled by their condition and unable to care for themselves. We’ve helped A-list celebrities, CEOs of Fortune 500 Companies, successful entrepreneurs, white-collar workers, blue-collar workers, people in-between jobs, students, and the unemployed. Some have chosen ketamine infusions as a first-line treatment, others have come to it at the end of a long, hard road of ineffective treatments.

Depression, other mood disorders, and chronic pain conditions don’t discriminate – these afflictions affect people from all walks of life. Fortunately, ketamine treatment isn’t selective either – it has the potential to heal anyone. The testimonials on this site and the 200+ five-star reviews across Google, Yelp, and other sites are heartfelt and inspiring. You can tell when you read these authentic, detailed, personal accounts that ketamine treatment at Ketamine Clinics Los Angeles (KCLA) has given people their lives back. We encourage you to read as many as you have time for; you just might read part of your own story.



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