The Leading Ketamine Clinic in Los Angeles since 2014!
Ketamine Clinics Los Angeles is a world-renowned, leading provider of Ketamine Therapy for the treatment of mood disorders. Since 2014, our mission has been to help those struggling with treatment-resistant conditions through an innovative, evidence-based, compassionate solution.
Infusions
Performed
Patients
Helped
Success
Rate
4 days
Rapid
Results
Zero
Long-Term
Side Effects
Over 83% of our mood disorder patients experience relief from their symptoms. Most patients see improvement in as fast as 4 hours to 4 days from when they start treatment. There are no known long-term side effects and the short-term side effects are well tolerated and usually dissipate within one day. All of these factors make Ketamine Infusion Therapy one of the fastest, most effective, and safest mood disorder treatments available today.
Ketamine for Depression and other Mood Disorders
At Ketamine Clinics of Los Angeles, we offer patients a personalized approach to mental health treatment, with ketamine infusions for depression, suicidal thinking, post-traumatic stress disorder (PTSD), anxiety, and other mood disorders. As one of the first Ketamine Clinics in the United States and the first and only Ketamine Clinic to be accredited by AAAASF, we consistently set the gold-standard for patient comfort, safety, and optimum treatment outcomes.
What We Treat

Depression
Patients undergoing Ketamine Infusion Therapy for depression, unipolar depression, bipolar depression, postpartum depression (PPD), can feel rapid relief within hours to days, without the negative side effects associated with antidepressant medications. Ketamine infusions for depression can be highly effective even in treatment-resistant cases. This return to wellness can last many months and even years in some cases, oftentimes eliminating the need to take antidepressants every day. Most patients also report a superior quality of relief; a genuine sense of happiness without the flat or numb affect often experienced from other treatments. Treatment is safe, effective, and has no long-term side effects.

Mood Disorders
Patients suffering from mood disorders such as suicidal thoughts, post-traumatic stress disorder (PTSD), obsessive-compulsive disorder and (OCD) may experience considerably more relief from ketamine infusions than conventional medications and therapies provide. Ketamine therapy can work effectively, even in treatment-resistant cases, with no long-term side effects. Ketamine helps improve brain function and promotes healing in a unique way, unlike other traditional treatments. Most of ketamine’s effects on neurochemistry are an entirely new approach to treating mental health conditions. Treatment is safe, effective, and has no long-term side effects.

Anxiety Disorders
Patients with generalized anxiety disorder, social phobia, panic disorder, and other forms of anxiety disorders can be treated effectively and quickly by Ketamine Infusion Therapy. Relief is often enjoyed as fast as 2-3 infusions. Ketamine treatment can help to promote calm in a patient’s nervous system through a unique process of helping restore a healthier neurochemical balance. Reductions in dependency on traditional prescription drugs are seen in some patients. Most patients enjoy an overall healthier perspective on themselves and their lives. Treatment is safe, effective, and has no long-term side effects

The care team at Ketamine Clinics Los Angeles (KCLA) is known for being the most experienced, knowledgeable, and compassionate providers in this field. We help patients feel at home during their treatments. Our state-of-the-art facility is purpose-built for this unique treatment and no expense was spared. On the top floor of the esteemed Cedars-Sinai Kerlan Jobe building in the Playa District, we blend luxurious amenities with cutting-edge medicine to create a serene, spa-like space for patients to enjoy one of the most effective treatments available for mood disorders. At KCLA, the patient experience is our highest priority and our ability to consistently deliver one that is 5-stars is evident in our awards, press coverage, reputation within the medical community, and over 200 five-star reviews.
We’re proud to be the premier clinic for ketamine therapy Los Angeles trusts. We foster a tight-knit team environment with committed employees who are among the most experienced and highly-trained to master this specialized treatment. Our combined proficiency and expertise with IV Ketamine Infusions for depression and other mood disorders ensures the best possible treatment outcomes for you and those you care for.
Press
The Doctors – Do Ketamine Clinics Need More Oversight?
Dr. Steven L. Mandel speaks on the Emmy award-winning TV show The Doctors about the oversight of Ketamine Clinics and where some doctors and other providers are crossing the line. He also educates viewers on ketamine’s multiple uses and the fact that it’s a depression treatment, not a cure.
BuzzFeed Video – How A Drug Helps Me Cope With My Kids’ Suicides
Wired Magazine – People are using ketamine to fight their depression.
Our articulate patient, Sean, shares his struggle with depression as an entrepreneur who “has it all” and how ketamine treatments helped him enjoy life again and function at a higher level. This WIRED Magazine video special also covers why Ketamine Infusions are such an effective treatment for depression. Thank you for sharing your story, Sean.
Research
Ketamine as a Novel Treatment for Major Depressive Disorder and Bipolar Depression: A Systematic Review and Quantitative Meta-Analysis
Given the significant disability, morbidity and mortality associated with depression, the promising recent trials of ketamine highlight a novel intervention. A meta-analysis was conducted to assess the efficacy of ketamine in comparison with placebo for the reduction of depressive symptoms in patients who meet criteria for a major depressive episode. The large and statistically significant effect of ketamine on depressive symptoms supports a promising, new and effective pharmacotherapy with rapid onset, high efficacy and good tolerability.
Antidepressant Efficacy of Ketamine in Treatment-Resistant Major Depression: A Two-Site Randomized Controlled Trial
The authors evaluated the rapid antidepressant efficacy of ketamine in a large group of patients with treatment-resistant major depression. Ketamine demonstrated rapid antidepressant effects in an optimized study design, further supporting NMDA receptor modulation as a novel mechanism for accelerated improvement in severe and chronic forms of depression.
Rapid Antidepressant Effects of Repeated Doses of Ketamine Compared with Electroconvulsive Therapy in Hospitalized Patients with Major Depressive Disorder
Accumulating evidence suggests that ketamine may exert rapid antidepressant effects in major depressive disorder patients. This study showed that ketamine is as effective as ECT in improving depressive symptoms in MDD patients and has more rapid antidepressant effects compared with the ECT.
Dr. Steven L. Mandel
Dr. Steven L. Mandel, Founder & President, is an internationally recognized expert and pioneer in the use of ketamine infusion therapy to treat mental health disorders. Dr. Mandel has more than 40 years of experience utilizing ketamine as a board-certified anesthesiologist. He also earned his master’s degree in psychology. He is the founder and president of Ketamine Clinics Los Angeles, a leading ketamine infusion therapy clinic in Southern California.
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