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TMS Therapy Side Effects: What Patients Should Know

Written by Ketamine Clinics Los Angeles | January 10, 2026

Understanding the potential side effects of TMS therapy empowers patients to make informed decisions about their mental health care journey.

Demystifying TMS Therapy: How It Works and Who Benefits

Transcranial Magnetic Stimulation (TMS) is a noninvasive, FDA-cleared therapy designed to help individuals with treatment-resistant depression and other mood disorders. TMS uses targeted magnetic pulses to stimulate specific regions of the brain associated with mood regulation, offering an alternative for those who haven’t found relief through traditional medications or therapy.

TMS is especially beneficial for patients who have not responded to multiple antidepressant trials or who experience intolerable side effects from medications. The therapy is conducted in a clinical setting, does not require anesthesia, and allows patients to return to their normal routines immediately after each session.

Common Side Effects: What Most Patients Experience

Most patients tolerate TMS therapy very well, but as with any medical procedure, some side effects can occur. The most common side effects are mild and temporary, including scalp discomfort or mild headache at the treatment site during or after sessions.

Other reported effects may include tingling or tapping sensations on the scalp, lightheadedness, or slight facial muscle twitching during stimulation. These effects typically diminish as the body acclimates to the therapy over the course of treatment.

Rare and Serious Risks: What to Watch For

Serious side effects with TMS are rare but important to recognize. The most significant risk is the potential for a seizure, which occurs in less than 0.1% of patients, typically those with pre-existing risk factors. Other rare risks may include hearing discomfort if ear protection is not used, or mood changes such as increased anxiety or agitation.

Clinicians conduct thorough screenings to minimize these risks, including reviewing medical history, assessing seizure risk, and ensuring that proper safety protocols are followed during each treatment session.

Managing Side Effects: Support and Strategies for Comfort

There are effective ways to manage the common, mild side effects of TMS. Adjusting the intensity of the magnetic pulses, repositioning the treatment coil, or pausing sessions briefly can greatly reduce discomfort. Over-the-counter pain relievers may also help with headaches, and most minor effects resolve quickly after sessions.

Patients are encouraged to communicate openly about any discomfort, as the clinical team can tailor the experience to maximize comfort and efficacy. Ongoing support throughout treatment helps ensure that side effects are promptly addressed and managed.

Open Communication: The Key to Safe, Effective Treatment

A trusting relationship between patients and their care team is essential for a safe and effective TMS experience. Patients should feel empowered to share any new or changing symptoms, ask questions, and discuss concerns at every step of their treatment journey.

Open communication allows clinicians to adjust protocols, address side effects promptly, and support patients in achieving the best possible outcomes. At KCLA, patient comfort, safety, and satisfaction are at the core of every treatment plan, ensuring each individual receives personalized, compassionate care.