Rapid, effective, and compassionate care in a safe, accredited clinic.
Rapid relief in hours to days.
Safe with no known long-term side effects and minimal short-term side effects.
83% success rate for treatment-resistant cases.
Administered by a skilled medical team in a safe setting.
Top Insurance Plans We Accept
KCLA offers up to 24 months of interest-free financing for self-pay patients. We are in network with most health insurance for TMS Therapy and Holistic Psychiatry. Some plans may also cover Ketamine Therapy, inquire for details.
Why Consider Ketamine Infusion Therapy?
Ketamine Infusion Therapy offers powerful, fast-acting relief for depression, anxiety, PTSD, and more. It’s a proven, individualized approach that offers new hope when other treatments haven’t worked. This isn’t just a treatment, but a journey towards a healthier, happier you.
Some insurance networks may cover it.
Safe with no known long-term side effects.
Avoids common side effects of prescription pills like SSRIs.
Effective even for treatment-resistant cases.
Supports profound transformations for the brain and the mind.
Ketamine infusion therapy uses low-dose intravenous ketamine infusions to quickly reduce symptoms of mood disorders. Originally FDA-approved as an anesthetic in 1970, ketamine is now used off-label for mental health and recognized by the World Health Organization (WHO) as an Essential Medicine.
At Ketamine Clinics Los Angeles (KCLA), we've provided over 35,000 infusions to more than 6,000 patients since 2014, with an 83% success rate.
At KCLA, your treatment typically includes a series of six intravenous (IV) ketamine infusions spaced over 2–3 weeks, with each session lasting about 50–55 minutes. For those traveling from out of town or with busy schedules, we also offer an accelerated protocol that delivers all 6 infusions over just 8 days.
Beyond infusions, we guide patients through preparation and integration, so you feel supported before, during, and after treatment.
How Does Ketamine Treatment Work?
Ketamine treatment supports healing in two ways: through direct brain chemistry and transformative experiences. These two essential, interrelated components are called the experiential and the neurochemical.
Experiential Effects
During your session, ketamine can create a gentle, dreamlike state that many people find deeply calming, introspective, or even spiritual. This experience can help quiet racing thoughts, loosen rigid negative patterns, and open up space for new, healthier perspectives.
Many patients notice their mood, behavior, and outlook begin to shift even while they're still in the infusion room, and these positive changes often last well beyond the treatment itself.
Neurochemical Effects
One important mechanism is boosting levels of brain-derived neurotrophic factor (BDNF), which promotes growth in the prefrontal cortex, helps repair damaged cells, and facilitates the creation of new connections between neurons. This neuroplasticity supports lasting improvements in mood and function.
Ketamine is an NMDA receptor antagonist that increases the production of the neurotransmitter glutamate and stimulates AMPA receptors. Glutamate is a crucial neurotransmitter involved in mood regulation, and imbalances can result in depression, anxiety, PTSD, and other mood disorders. By restoring healthy glutamate signaling, ketamine helps rebalance brain chemistry when traditional treatments have been ineffective.
If you're living with treatment-resistant depression, we understand how discouraging it can feel when nothing seems to help. Ketamine treatment near you offers a new path forward, one that works quickly to ease symptoms and restore hope.
At KCLA, we use ketamine to help people find meaningful relief from many forms of depression, including:
Major Depressive Disorder
Bipolar Depression
Persistent Depressive Disorder
Postpartum Depression
Ketamine Therapy for Anxiety Disorders
Struggling with anxiety that feels impossible to manage? Our Ketamine Therapy in Los Angeles offers an innovative, effective option for those whose symptoms haven't improved with standard treatments.
Our approach provides rapid relief from intense, debilitating anxiety while also supporting longer-term improvements in mood and daily functioning. We see positive results for people living with Generalized Anxiety Disorder, Panic Disorder, and other anxiety-related conditions, helping them reclaim calm, balance, and a sense of control.
Ketamine Therapy for Trauma and PTSD
Trauma-related disorders like PTSD and Complex PTSD can be challenging to treat, but ketamine’s dissociative and neuroplastic effects offer a new avenue for healing. Patients often report symptom reduction, fresh insights, and long-term progress.
Ketamine Therapy for Addiction
Ketamine therapy near you can be a supportive tool in breaking addiction cycles. It helps quiet compulsive behaviors and promotes new mental pathways, making it easier to adopt healthier habits when paired with ongoing care and support.
Ketamine Therapy for Obsessive-Compulsive Disorder (OCD)
Living with OCD can feel exhausting and overwhelming, especially when traditional treatments haven't worked. Ketamine therapy offers hope by enhancing the brain's ability to form new connections and interrupt rigid, intrusive thought patterns. Many patients experience meaningful relief from symptoms and an improved ability to engage fully in daily life.
At KCLA, we understand that true healing encompasses more than just medicine itself. That's why we place importance on preparation and integration. These supportive sessions help you set clear intentions, feel safe and grounded during your experience, and apply the insights you gain in a meaningful, lasting way.
Ketamine Preparation Session
Before your treatment, you'll meet with your provider to:
Set personal goals for your ketamine sessions.
Learn what to expect before, during, and after.
Develop strategies for staying grounded.
Build trust with your care team.
Understand how mindset and environment ("set and setting") shape your experience.
Begin planning for post-treatment integration.
Ketamine Integration Session
After your session, integration helps turn insights into lasting change. You and your KCLA Provider will:
Reflect on the experience.
Identify emotional shifts and breakthroughs.
Work through anything confusing or intense.
Apply lessons to your daily life and relationships.
Note: Preparation and integration sessions are distinct from your ketamine infusion sessions, so please schedule accordingly. Speak with your Care Coordinator for details.
Is Ketamine Infusion Therapy Safe?
Safety is our top priority at Ketamine Clinics Los Angeles (KCLA), and we have pioneered the gold standard in this field since 2014. We continue to evolve with the latest scientific breakthroughs to ensure every patient's experience is as safe, comfortable, and effective as possible.
Our team of board-certified physicians and psychiatric clinicians has delivered over 35,000 ketamine infusions. Every patient begins with a comprehensive medical evaluation to confirm that ketamine is an appropriate and safe treatment option.
During every session, your vitals (including heart rate, blood pressure, and oxygen) are closely monitored. Our team holds advanced certifications (ACLS, ASA Moderate Sedation, BLS) to ensure safe, expert care.
KCLA is proud to be the first and only Ketamine Clinic accredited by Quad A, meeting rigorous standards for safety, emergency supplies and equipment, and training. At KCLA, you can expect trusted, expert-led care every step of the way.
Ketamine for depression has been studied extensively by top institutions worldwide. It’s one of the most researched and effective therapies for depression available today, with over 90 clinical trials with results published on clinicaltrials.gov alone.
Important Safety Note: At KCLA, we use ketamine only in safe, medical settings. Street use or unsupervised consumption is dangerous and potentially life-threatening. Always seek care from trained, licensed professionals.
At KCLA, we provide safe, effective, and compassionate care. Founded in 2014, we are among the first, largest, and most respected ketamine clinics globally.
Proven Expertise
Our family-founded practice has performed over 35,000 treatments for more than 6,000 patients. Our team of board-certified medical professionals includes an anesthesiologist, psychiatrists, psychiatric nurse practitioners, and registered nurses supported by a compassionate administrative staff to deliver personalized, evidence-based care.
Exceptional Safety Standards
Patient safety is our highest priority. We maintain advanced certifications, including ACLS, ASA Moderate Sedation, and BLS. As the first and only Ketamine Clinic accredited by Quad A, we meet rigorous standards for safety, training, and equipment. During every session, we closely monitor vitals like heart rate, oxygen saturation, blood pressure, and, when indicated, EKG.
Unlike standard IV bags, we use digital syringe pumps for precise, customizable dosing. This real-time titration enhances both safety and effectiveness while maintaining consistent care.
Demonstrated Effectiveness
KCLA has an 83% success rate in helping patients achieve relief from depression, anxiety, PTSD, and other mood disorders, even when other treatments have failed. We track your progress using validated tools like the BDI-II, MADRS, PHQ-9, and GAD-7.
Innovative, Personalized Approach
Our unique Mandel Method® offers individualized dosing, a broader dosing spectrum, 38% longer infusions than most, and an enhanced therapeutic setting designed for patient comfort and success.
Comprehensive Preparation and Integration
Our team of board-certified mental health professionals helps patients achieve lasting change through comprehensive prep and integration. We also offer innovative virtual reality preparation to help patients relax and mentally prepare for their infusion sessions; a unique feature designed to reduce anxiety and enhance the therapeutic experience.
Comfortable, Private, and Calming Environment
Each patient enjoys a private room equipped with a premium infusion recliner, noise-cancelling headphones, unlimited music selection, pillows, blankets, and a sleep mask. Our state-of-the-art clinic is a serene, beautiful, and calming environment that fosters healing, promotes peace of mind, and enhances a positive therapeutic experience.
Accessible, Comprehensive Care
Located in Los Angeles' Playa District, our advanced facility offers a full range of innovative mental health treatments under one roof. We provide seamless onboarding with same-week appointments, both in-person and telehealth options, and accept many major insurance plans for additional services.
Trusted by Patients and Professionals
With over 500 five-star reviews, KCLA is trusted and respected by patients and referring medical professionals worldwide for delivering safe, effective, and compassionate ketamine infusion therapy.
"If I were told there is a medicine and you can live life again, like you can not just live life, but you can be excited about life again, I would’ve turned to this a long, long time ago."
AJ
"It started working pretty much immediately."
Joseph
"It was the best thing I could’ve ever done in my life! I will always be grateful for it."
Jana
"I do ketamine infusions at Ketamine Clinics Los Angeles, and they absolutely have saved my life!"
Ariel
"Ketamine Therapy completely changed my entire outlook on life!"
Sara
"The infusions were a really beautiful experience…almost like visual poetry of my life. The results were concrete and powerful."
Anna
"Ketamine Therapy with Ketamine Clinics Los Angeles saved my life."
Meg
"I am a much calmer person, I am a happier person, I am more resilient."
Justin
"I never thought I would come back to this beach. The first time I was able to come here was last year after receiving my ketamine treatments."
Kevin
"Immediately after, I’d say the first two months of infusions, I took a chance and sang in front of people again… thought I never would have."
Cami
"I got ketamine infusions and right away my suicidal thoughts were gone and within a few short sessions I was feeling so much better."
Autumn
"It’s finally the ketamine that has fundamentally changed the way that I think for the better."
Shira
"I was pleasantly surprised by the effectiveness of the ketamine infusions. They really work to tamp down the negative voices that chatter away in our heads, if not extinguish them."
Who is a Good Candidate for Ketamine Infusion Therapy?
Adults with mood disorders like depression, anxiety, PTSD, OCD, PPD, or SUD may benefit, especially those who haven’t found relief through traditional treatments. Increasingly, people seek ketamine as a first-line therapy. No referral is needed, but we may consult your care team with your permission.
How Does Ketamine Work in the Brain?
Ketamine has powerful neuroplastic effects. It increases neurotransmitters like glutamate and promotes the growth of new neural connections in the prefrontal cortex, helping repair damaged pathways associated with mood regulation. The results can lead to rapid improvements in depression and anxiety symptoms, even when other treatments have failed.
Is Ketamine Infusion Therapy Safe? What Are the Side Effects?
Ketamine infusions are safe when administered by experienced clinicians in a medical setting. The most common side effects are mild and temporary, including grogginess and nausea. We proactively manage these with anti-nausea medication when needed. Patients typically feel back to normal after a good night's sleep. There are no known long-term side effects when used responsibly under medical supervision.
Is Ketamine Addictive?
When used in a clinical setting, the risk is extremely low. Addiction risks are linked to frequent, high-dose recreational use, not the carefully controlled, low-dose treatments we provide.
How Many Ketamine Infusions Will I Need?
Most patients receive an initial series of six infusions, typically administered over 2 to 3 weeks.
In some cases, we extend the initial series to 8 or 10 infusions over an additional 1-2 weeks.
Our accelerated protocol consists of 6 infusions administered over 8 days.
After the initial series, patients return for booster infusions on an as-needed basis, typically every 2-3 months, with decreasing frequency over time. Many patients require only 2–3 maintenance infusions per year.
What Does Ketamine Treatment Feel Like?
Most patients experience mild dissociation, characterized by increased sensitivity to light and sound, as well as altered perception of time. Many describe the experience as calming, insightful, and healing. These effects typically subside within 20 to 30 minutes after the session ends. Patients remain awake, alert, and able to communicate with their care team throughout their session.
Will Ketamine Therapy Help if I Have Treatment-Resistant Depression?
Yes, ketamine is especially effective in such cases. At KCLA, 83% of patients with treatment-resistant depression see improvement. Some feel results after just one infusion; most notice progress by the third. Boosters help maintain these benefits long-term.
Does Insurance Cover Ketamine Therapy?
Insurance coverage is limited since IV ketamine is off-label. Some insurers cover treatment through contracts with us. Our team will explore your options and provide interest-free financing if needed.
How Much Does Ketamine Therapy Cost?
Costs vary by care plan and insurance. We offer free consultations to discuss pricing, coverage, and payment options with no obligation.
What Should I Expect at KCLA During My Ketamine Treatment?
On your first visit, you’ll complete onboarding forms, then meet with your provider for a prep session (if included in your plan). You’ll then receive your infusion in a private room, with complete monitoring by our care team.
Infusions last about 50–55 minutes. Expect to spend 2.5 hours on your first visit and 90-120 minutes on return visits. Afterward, we’ll provide light refreshments and make sure you're ready to go. You’ll need a ride home and should rest for the remainder of the day.
