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Ketamine Infusion Therapy in Los Angeles for Depression, Anxiety, PTSD, and More

 

Rapid, effective, and compassionate care in a safe, accredited clinic.

  • Rapid relief in hours to days. 
  • 83% success rate for treatment-resistant cases.
  • Safe, expert medical team.

Why Consider Ketamine Infusion Therapy?

Ketamine Infusion Therapy is a highly effective, transformative experience tailored to you.

  • May be covered by some insurance networks.
  • Safe with no long-term side effects.
  • Without the common side effects of prescription pills like SSRIs.
  • Effective even for treatment-resistant cases.
  • Supports profound transformations for the brain and the mind. 
Am i a candidate for ketamine treatment?
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What is Ketamine Infusion Therapy?

Ketamine Infusion Therapy is a transformational treatment that can rapidly relieve symptoms of depression, anxiety, PTSD, and other mood disorders—often within hours. Originally approved by the FDA in 1970 as an anesthetic and recognized by the World Health Organization as an Essential Medicine since 1985, ketamine has since been prescribed off-label for its powerful mental health benefits.

At Ketamine Clinics Los Angeles (KCLA), we’ve been delivering this innovative care since 2014, providing over 35,000 infusions to more than 6,000 patients with an 83% success rate.

At carefully controlled, lower doses, ketamine can disrupt harmful thought patterns, reduce distressing symptoms, and help the brain form new, healthier connections, offering relief when other treatments have failed.

At KCLA, treatment typically involves a series of six intravenous (IV) ketamine infusions over a 2–3 week period, with each session lasting 50–55 minutes. We offer an accelerated protocol of 6 infusions over 8 days for travelers and those with scheduling limitations. Most patients also participate in our comprehensive preparation and integration program, which helps them set clear intentions, feel safe and supported, and apply insights from their journey in a meaningful way for lasting mental health and healing.

How Does Ketamine Treatment Work?

Ketamine has powerful, multi-layered effects on the brain and mind. Treatment can be understood through two distinct components: the experiential effects and the neurochemical effects.

Experiential Effects:
During treatment, ketamine induces a mild dissociative state that many patients describe as therapeutic, meditative, or even spiritual. This experience can disrupt rigid, negative thought patterns and open space for new perspectives. Positive shifts in mood, behavior, and outlook often begin during the infusion itself and can be sustained long after treatment is complete. 

Neurochemical Effects:
One important mechanism is boosting levels of brain-derived neurotrophic factor (BDNF), which promotes growth in the prefrontal cortex, helps repair damaged cells, and creates new connections between neurons. This neuroplasticity supports lasting improvements in mood and function.

Ketamine also acts as an NMDA receptor antagonist, which increases glutamate production and stimulates AMPA receptors. Glutamate is a crucial neurotransmitter involved in mood regulation, and imbalances are often linked to depression and anxiety. By restoring healthy glutamate signaling, ketamine helps rebalance brain chemistry when traditional treatments have been ineffective.

Getting started is just 3 quick, easy steps:

  1. Free phone consultation.
  2. Provider intake call.
  3. Begin your path to wellness.
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What Does Ketamine Treat?

Ketamine Therapy for Depression

Ketamine Infusion Therapy offers rapid, effective relief for individuals struggling with treatment-resistant depression. It can help address various forms of depression, including Major Depressive Disorder, Bipolar Depression, Persistent Depressive Disorder, and Postpartum Depression. By working quickly to alleviate symptoms, ketamine provides hope for those who have not found relief with traditional medications or treatments.

Ketamine Therapy for Anxiety Disorders

Ketamine Therapy can be an effective option for those living with debilitating anxiety that has not responded to standard treatments. It can provide rapid symptom relief and support long-term improvements in mood and functioning. Indications include Generalized Anxiety Disorder, Panic Disorder, and other anxiety-related conditions.

Ketamine Therapy for Trauma and PTSD

Ketamine Therapy is increasingly recognized as a valuable treatment for trauma-related conditions, including PTSD and Complex PTSD. Its neuroplastic and dissociative effects can help patients gain new perspectives, reduce distressing symptoms, and therapeutically process traumatic memories. When properly supported, ketamine therapy can offer meaningful relief and support lasting healing.

Ketamine Therapy for Addiction

Ketamine Infusion Therapy shows promise as an innovative treatment for certain substance use disorders. Its neuroplastic and dissociative effects can help disrupt entrenched patterns of craving and compulsive behavior, supporting the development of healthier coping strategies. When integrated with comprehensive care and psychotherapy, ketamine can aid in reducing relapse risk and promoting lasting recovery.

Ketamine Therapy for Obsessive-Compulsive Disorder (OCD)

Ketamine Therapy may provide rapid relief for individuals struggling with severe or treatment-resistant OCD. By enhancing neuroplasticity and interrupting rigid, intrusive thought patterns, ketamine can help reduce symptom severity and improve daily functioning. It offers hope for those who have not responded to traditional medications or therapies alone.

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Is Ketamine Infusion Therapy Safe?

Safety is our top priority at Ketamine Clinics Los Angeles (KCLA), and we have pioneered the gold standard in this field since 2014. We implement the latest science-backed protocols to ensure every patient’s experience is as safe, comfortable, and effective as possible.

Our program is led by board-certified psychiatric clinicians with extensive experience, having safely delivered over 35,000 ketamine infusions. Every patient begins with a comprehensive medical evaluation to confirm that ketamine is an appropriate and safe treatment option.

Our trusted medical experts carefully oversee your comfort and safety throughout each treatment session. Vital signs—including heart rate, oxygen saturation, blood pressure, and EKG when indicated—are continuously monitored to ensure your well-being.

Our team maintains advanced certifications, including ACLS, ASA Moderate Sedation, and BLS, reflecting our commitment to the highest standards of clinical care.

KCLA is proud to be the first and only Ketamine Clinic accredited by Quad A, meeting rigorous standards for safety, emergency supplies and equipment, and training.

At KCLA, you can expect trusted, expert-led care every step of the way.

Ketamine for depression has been extensively studied in over 90 clinical trials with results, including those sponsored by the NIMH. It’s considered one of the safest and best-tolerated treatments for depression available today.

Important Safety Note:
At Ketamine Clinics Los Angeles, we are dedicated to the safe, ethical, and therapeutic use of ketamine in a controlled medical setting. Using ketamine outside of clinical supervision—such as street ketamine or non-prescribed forms—can be dangerous and even life-threatening. We strongly discourage any non-medical use and urge patients to seek treatment only under the care of qualified medical professionals.

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Why Choose Ketamine Clinics Los Angeles (KCLA)?

At Ketamine Clinics Los Angeles (KCLA), we’re committed to delivering the safest, most effective, and most compassionate care available. Founded in 2014, we are among the first, largest, and most respected ketamine clinics globally.

Proven Expertise
 Our family-founded practice has performed over 35,000 treatments for more than 6,000 patients. Our team of board-certified medical professionals includes an anesthesiologist, psychiatrists, and psychiatric nurse practitioners supported by registered nurses and dedicated support staff—all working together to deliver personalized, evidence-based care.

Exceptional Safety Standards
 Patient safety is our highest priority. We maintain advanced certifications, including ACLS, ASA Moderate Sedation, and BLS. As the first and only Ketamine Clinic accredited by Quad A, we meet rigorous standards for safety, training, and equipment. Every patient’s vitals—including heart rate, oxygen saturation, blood pressure, and EKG when indicated—are carefully monitored during treatment.

We use advanced digital syringe pumps instead of standard IV bags to deliver precise, customizable dosing tailored to each patient’s needs. This approach enables real-time titration to effect, maximizing both safety and therapeutic benefit while ensuring continuity of care throughout the infusion.

Demonstrated Effectiveness
 KCLA has an 83% success rate in helping patients achieve relief from depression, anxiety, PTSD, and other mood disorders—even when other treatments have failed. We utilize validated mood-monitoring tools, including the BDI-II, MADRS, PHQ-9, and GAD-7, to track progress and ensure meaningful outcomes.

Innovative, Personalized Approach
Our unique Mandel Method® offers individualized dosing, a broader dosing spectrum, 38% longer infusions, and an enhanced therapeutic setting designed for patient comfort and success. 

Comprehensive Preparation and Integration

Our team of board-certified mental health professionals helps patients achieve lasting change through comprehensive prep and integration. We also offer innovative virtual reality preparation to help patients relax and mentally prepare for their infusion sessions—a unique feature designed to reduce anxiety and enhance the therapeutic experience.

Comfortable, Private, and Calming Environment
 Each patient enjoys a private room equipped with a premium infusion recliner, noise-cancelling headphones, unlimited music selection, pillows, blankets, and a sleep mask throughout their infusion sessions to ensure comfort, confidentiality, and personalized attention. Our state-of-the-art clinic is designed to be serene, beautiful, and calming, creating an environment that fosters healing, promotes peace of mind, and enhances a positive therapeutic experience.

Accessible, Comprehensive Care
 Located in Los Angeles’ Playa District, our advanced facility offers a full range of innovative mental health treatments under one roof. We provide seamless onboarding with same-week appointments, both in-person and telehealth options, and accept many major insurance plans for additional services.

Trusted by Patients and Professionals
 With over 500 five-star reviews across various review platforms, KCLA is trusted and respected by patients and referring medical professionals worldwide for delivering safe, effective, and compassionate ketamine therapy.
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Real people, real results.

"Your clinic, you, saved my life!"

Autumn

"If I were told there is a medicine and you can live life again, like you can not just live life, but you can be excited about life again, I would’ve turned to this a long, long time ago."

AJ

"It started working pretty much immediately."

Joseph

"It was the best thing I could’ve ever done in my life! I will always be grateful for it."

Jana

"I do ketamine infusions at Ketamine Clinics Los Angeles, and they absolutely have saved my life!"

Ariel

"Ketamine Therapy completely changed my entire outlook on life!"

Sara

"The infusions were a really beautiful experience…almost like visual poetry of my life. The results were concrete and powerful."

Anna

"Ketamine Therapy with Ketamine Clinics Los Angeles saved my life."

Meg

"I am a much calmer person, I am a happier person, I am more resilient."

Justin

"I never thought I would come back to this beach. The first time I was able to come here was last year after receiving my ketamine treatments."

Kevin

"Immediately after, I’d say the first two months of infusions, I took a chance and sang in front of people again… thought I never would have."

Cami

"I got ketamine infusions and right away my suicidal thoughts were gone and within a few short sessions I was feeling so much better."

Autumn

"It’s finally the ketamine that has fundamentally changed the way that I think for the better."

Shira

"I was pleasantly surprised by the effectiveness of the ketamine infusions. They really work to tamp down the negative voices that chatter away in our heads, if not extinguish them."

Emile
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Reclaim Hope. Reclaim Life. 

You can start your journey to rapid relief with a free consultation today. 

Meet The Team
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Ketamine Therapy FAQs

General Questions

What is ketamine infusion therapy?
Ketamine Infusion Therapy is the use of ketamine for the treatment of mood disorders and pain conditions, most commonly depression, suicidal ideation, posttraumatic stress disorder (PTSD), and complex regional pain syndrome (CRPS). For the treatment of mood disorders, ketamine therapy involves a series of six infusions at a ketamine infusion center spaced out over 2-3 weeks, with each infusion lasting about one hour. The dissociative effects of ketamine subside quite quickly, with most patients feeling comfortable enough to go home 20-30 minutes after the infusion is complete. For pain conditions, ketamine treatment involves a series of five, higher dose infusions at a ketamine infusion clinic over five days, with each infusion lasting about four hours.
What does ketamine do to your brain?

Mood disorder patients often get rapid results from ketamine infusion. When given through an intravenous infusion in a slow, controlled, and constant rate, ketamine has many highly therapeutic effects on the brain. Among them is the ability to cause physical growth in the brain’s prefrontal cortex, establishing new connections between neurons while repairing damaged cells. Ketamine causes an increase in neurotransmitters like glutamate that help to build new pathways in the brain, improving function in areas of mood, sleep, and more.

Pain patients often suffer from a process known as “central sensitization,” where pain signals increase in frequency and intensity over time. Ketamine acts to reset pain receptors and block signals of pain, restoring a healthier balance.

What is esketamine/Spravato and how is it different from the ketamine used in intravenous infusions?

We infuse ketamine intravenously and esketamine AKA Spravato is taken intranasally. We provide ketamine intravenously because the IV route of administration (ROA) offers a number of safety and efficacy advantages. Please schedule a call with us to discuss the pros and cons of both treatment options.

Concerns

Are ketamine infusions addictive?
No. As one of the leading ketamine clinics LA has to offer, we’ve provided ketamine therapy to many patients and not a single one has reported any symptoms of addiction.
Are there any other side effects I should be concerned about?

Patients commonly feel tired or groggy after an infusion. This usually subsides completely after a full night of sleep. Some patients experience mild nausea after an infusion, especially those prone to motion sickness. If you are prone to nausea, we can administer anti nausea medicine before the infusion to help prevent it. Additionally, patients who experience nausea after an infusion usually feel much better after we provide additional anti nausea medicine. Side effects usually dissipate within a few hours and are usually completely gone by the following day. There are no known long-term side effects of IV Ketamine Infusion Therapy when administered by a responsible clinician in a medical setting.

I don't have a psychiatrist, is that a problem?

We do not require a referral or prescription from a psychiatrist or other physician. We do require speaking with another clinician who has managed the condition for which you are seeking treatment. This is to confirm your diagnosis, learn more about you, and personalize your treatment plan. The clinician can be a psychiatrist, psychologist, therapist, general practitioner, or pain specialist. All patients are encouraged to engage in talk therapy and implement positive lifestyle changes.

 

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Top Insurance Plans We Accept

aetna Anthem Blue-Shield Carelon Cigna Compsych Enthea Kaiser Magellan Medicare MHN Optum Tricare TRIWEST
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