Spravato (esketamine nasal spray) is the only FDA-approved ketamine nasal spray in Los Angeles for depression and suicidal ideation that’s covered by most major insurance plans.
Relief can begin within hours or days.
Administered in a serene, private Spravato clinic.
Overseen by licensed, experienced clinicians.
Proven safety profile with strict monitoring standards.
Spravato treatment refers to a nasal spray formulation of esketamine, the S-enantiomer of ketamine. While traditional ketamine is used off-label for mood disorders, Spravato is FDA-approved specifically for depression, which allows for insurance reimbursement in most cases.
This in-clinic, self-administered therapy is monitored closely by trained staff. Patients remain onsite for at least two hours after dosing, and care is coordinated with psychiatric prescribers for continuity and better outcomes.
How Does Spravato Work?
Unlike SSRIs that affect serotonin over weeks, Spravato targets NMDA receptors and increases glutamate, which can promote neuroplasticity, helping the brain form new, mood-regulating neural pathways.
Most patients feel better after 3–4 sessions, with some noticing improvements in as little as 24 hours. At KCLA, we often combine Spravato with oral antidepressants and supportive psychotherapy for a more comprehensive mental health plan. Our services also include IV Ketamine Infusion Therapy, TMS, Holistic Psychiatry, and guided preparation and integration support.
What Does Spravato Treat?
Spravato is FDA-approved for:
Treatment-Resistant Depression (TRD).
Major Depressive Disorder (MDD) with suicidal ideation.
Spravato may also help patients who:
Have not found relief with two or more traditional antidepressants.
Want to avoid the side effects of traditional medications.
Require rapid symptom relief, especially in crises.
Safe, Structured Care with REMS-Certified Treatment
Spravato is delivered through a carefully controlled, FDA-required program called REMS (Risk Evaluation and Mitigation Strategy). Only certified providers like KCLA can offer this Spravato treatment in compliance with strict safety protocols.
What to Expect in the First Month
The Induction Phase typically involves two sessions per week. Most patients begin at 56mg, with the option to increase to 84mg. We check in before every session to make sure you’re comfortable and supported.
Tapering (Month 2): Weekly or biweekly sessions based on symptom improvement
Maintenance: Custom schedule, typically every 1 to 4 weeks
Patients frequently ask us, "Can Spravato Be Taken at Home?" and the answer is no. Due to REMS guidelines, Spravato must be administered in a certified Spravato clinic, with patients monitored onsite for at least two hours post-dose.
Spravato is FDA-approved and carefully monitored for safety:
Administered only in certified medical settings
Supervised by licensed providers throughout each session
We monitor all significant vital signs during treatment
Common, short-lived side effects
Dizziness or lightheadedness
Floating sensations
Mild dissociation or perceptual changes
Nausea
Most patients find these effects manageable and short-lasting. Patients must have someone drive them home after sessions and should refrain from driving for the remainder of the day. Unlike many traditional antidepressants, Spravato does not typically cause weight gain or sexual dysfunction.
"I'd like to share my whole-hearted endorsement of Ketamine Clinics Los Angeles."
Dr. Nina Savelle-Rocklin
"Your clinic, you, saved my life!"
Autumn
"If I were told there is a medicine and you can live life again, like you can not just live life, but you can be excited about life again, I would’ve turned to this a long, long time ago."
AJ
"It started working pretty much immediately."
Joseph
"It was the best thing I could’ve ever done in my life! I will always be grateful for it."
Jana
"I do ketamine infusions at Ketamine Clinics Los Angeles, and they absolutely have saved my life!"
Ariel
"Ketamine Therapy completely changed my entire outlook on life!"
Sara
"The infusions were a really beautiful experience…almost like visual poetry of my life. The results were concrete and powerful."
Anna
"Ketamine Therapy with Ketamine Clinics Los Angeles saved my life."
Meg
"I am a much calmer person, I am a happier person, I am more resilient."
Justin
"I never thought I would come back to this beach. The first time I was able to come here was last year after receiving my ketamine treatments."
Kevin
"Immediately after, I’d say the first two months of infusions, I took a chance and sang in front of people again… thought I never would have."
Cami
"I got ketamine infusions and right away my suicidal thoughts were gone and within a few short sessions I was feeling so much better."
Autumn
"It’s finally the ketamine that has fundamentally changed the way that I think for the better."
Shira
"I was pleasantly surprised by the effectiveness of the ketamine infusions. They really work to tamp down the negative voices that chatter away in our heads, if not extinguish them."
Why Choose Ketamine Clinics Los Angeles for Spravato?
Experience You Can Count On
Since 2014, we’ve helped over 6,000 patients and performed more than 35,000 ketamine treatments in Los Angeles.
A Thoughtful, Personalized Approach
We understand that everyone’s journey is unique, which is why we invest in truly understanding you—your history, what you’ve tried before, and how you’re feeling now. If you’re already working with other providers, we’ll collaborate with them to make sure your care is seamless and well-coordinated.
And because we offer comprehensive psychiatric services, you’ll have easy access to the latest, most effective treatments—all in one supportive place.
A Private, Calming Setting Designed for You
Your session takes place in a private room with curated music, noise-canceling headphones, premium recliners, and warm blankets. Our compassionate staff supports you every step of the way.
Certified for the Highest Standards of Safety
We’re fully certified to administer Spravato under the FDA’s REMS program, which ensures the highest standards in safety and quality. As the first and only Ketamine Clinic accredited by Quad A, we meet rigorous benchmarks for training, staffing, equipment, and protocols, giving you complete peace of mind.
Insurance-Friendly and Hassle-Free
Most major insurers typically cover Spravato for eligible patients, and we’re in-network with most of them. Our experienced team will help verify your benefits, clearly explain your costs, and handle the paperwork, so you can focus on what matters most: feeling better.
Integrated, Ongoing Support
We believe effective care doesn’t end with the treatment session. We partner with your psychiatric and therapy providers for smooth, coordinated care. And if you don’t already have providers, we can help connect you with comprehensive, wraparound mental health support. Our preparation and integration program ensures you’re ready for your Spravato experience and can carry its benefits into your daily life.
KCLA offers up to 24 months of interest-free financing for self-pay patients. We are in network with most health insurance for TMS Therapy and Holistic Psychiatry. Some plans may also cover Ketamine Therapy, inquire for details.
